Diclofenac-d4

Diclofenac-d4 is intended for use as an internal standard for the quantification of diclofenac (Cay-70680, Cay-22983) by GC- or LC-MS. Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 0.9-2.7 and 1.5-20 µM, for human COX-1 and COX-2, respectively). It is also an active metabolite of diclofenac methyl ester (Cay-22218) and diclofenac amide (Cay-21969). Diclofenac inhibits release of arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) induced by A23187 (Cay-11016) in isolated rat peritoneal neutrophils and macrophages (IC50s = 60 and 10 µM, respectively). Transdermal administration of diclofenac inhibits carrageenan-induced paw edema in rats. Formulations containing diclofenac have been used in the treatment of pain associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.Formal Name: 6-[(2,6-dichlorophenyl)amino]-benzene-2,3,4,5-d4-acetic acid. CAS Number: 153466-65-0. Molecular Formula: C14H7D4Cl2NO2. Formula Weight: 300.2. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: DMSO: 30 mg/ml, Ethanol: 30 mg/ml. SMILES: ClC1=C(N([H])C2=C(CC(O)=O)C([2H])=C([2H])C([2H])=C2[2H])C(Cl)=CC=C1. InChi Code: InChI=1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19)/i1D,2D,4D,7D. InChi Key: DCOPUUMXTXDBNB-SCFZSLNVSA-N.