diABZI STING Agonist 2

diABZI STING agonist 2 is an agonist of stimulator of interferon genes (STING). It binds to STING with an apparent Kd value of 1.6 nM. It is selective for STING over the acute phase reactant orosomucoid 1 (ORM1, apparent Kd = 79 nM). diABZI STING agonist 2 increases phosphorylation of interferon regulatory factor 3 (IRF3) and STING in human peripheral blood mononuclear cells (PBMCs). It also induces secretion of IFN-beta from PBMCs (EC50 = 3.1 µM).Formal Name: 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-1H-benzimidazole-5-carboxamide. CAS Number: 2138300-40-8. Synonyms: CS-0087594, diABZI Stimulator of Interferon Genes Agonist 2, Diamidobenzimidazole STING Agonist-2, Diamidobenzimidazole Stimulator of Interferon Genes Agonist 2, HY-123943, STING Agonist diABZI Compound 2, STING Agonist (Compound 4), STING Agonist 4, Stimulator of Interferon Genes Agonist (Compound 4), Stimulator of Interferon Genes Agonist 4. Molecular Formula: C34H38N12O4. Formula Weight: 678.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: slightly soluble. SMILES: NC(C1=CC=C(C(N=C2NC(C3=CC(C)=NN3CC)=O)=C1)N2CCCCN4C5=CC=C(C(N)=O)C=C5N=C4NC(C6=CC(C)=NN6CC)=O)=O. InChi Code: InChI=1S/C34H38N12O4/c1-5-45-27(15-19(3)41-45)31(49)39-33-37-23-17-21(29(35)47)9-11-25(23)43(33)13-7-8-14-44-26-12-10-22(30(36)48)18-24(26)38-34(44)40-32(50)28-16-20(4)42-46(28)6-2/h9-12,15-18H,5-8,13-14H2,1-4H3,(H2,35,47)(H2,36,48)(H,37,39,49)(H,38,40,50). InChi Key: ICZSAXDKFXTSGL-UHFFFAOYSA-N.