Desglymidodrine

Desglymidodrine is the active metabolite of the prodrug midodrine (Cay-17349). It is formed from midodrine by enzymatic hydrolysis. Desglymidodrine is an agonist of alpha1-adrenergic receptors (alpha1-ARs). It binds to alpha1-ARs (Kis = 9.77, 9.55, and 8.51 µM for alpha1A, alpha1B, and alpha1D-ARs, respectively) and increases intraurethral pressure (IUP) and mean arterial pressure (MAP) by 5 and 20 mm Hg, respectively, in anesthetized dogs at doses of 205 and 250 nmol/kg, respectively.Formal Name: alpha-(aminomethyl)-2,5-dimethoxy-benzenemethanol. CAS Number: 3600-87-1. Synonyms: ST 1059. Molecular Formula: C10H15NO3. Formula Weight: 197.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 1 mg/ml, DMSO: 2 mg/ml, Ethanol: insol, PBS (pH 7.2): insol. SMILES: OC(CN)C1=C(OC)C=CC(OC)=C1. InChi Code: InChI=1S/C10H15NO3/c1-13-7-3-4-10(14-2)8(5-7)9(12)6-11/h3-5,9,12H,6,11H2,1-2H3. InChi Key: VFRCNXKYZVQYLX-UHFFFAOYSA-N.