Deracoxib

Deracoxib is a non-steroidal anti-inflammatory drug (NSAID) and selective inhibitor of COX-2 (IC50s = 0.63 and 23 µM for COX-2 and COX-1, respectively). In vivo, deracoxib (0.3-10 mg/kg) increases weight bearing and decreases lameness and joint effusion in a canine model of urate crystal-induced intraarticular synovitis. Deracoxib induces less lesion formation in the gastric mucosa of healthy canines than aspirin (Cay-70260) when administered at a dose of 1.5 mg/kg. Formulations containing deracoxib have been used in the treatment of pain associated with canine osteoarthritis.Formal Name: 4-[3-(difluoromethyl)-5-(3-fluoro-4-methoxyphenyl)-1H-pyrazol-1-yl]-benzenesulfonamide. CAS Number: 169590-41-4. Synonyms: SC-59046. Molecular Formula: C17H14F3N3O3S. Formula Weight: 397.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMF:PBS (pH 7.2) (1:8): 0.1 mg/ml, DMSO: 10 mg/ml, Ethanol: 3 mg/ml. lambdamax: 256 nm. SMILES: FC1=CC(C2=CC(C(F)F)=NN2C3=CC=C(S(N)(=O)=O)C=C3)=CC=C1OC. InChi Code: InChI=1S/C17H14F3N3O3S/c1-26-16-7-2-10(8-13(16)18)15-9-14(17(19)20)22-23(15)11-3-5-12(6-4-11)27(21,24)25/h2-9,17H,1H3,(H2,21,24,25). InChi Key: WAZQAZKAZLXFMK-UHFFFAOYSA-N.