Dendrobine

Dendrobine is a sesquiterpenoid that has been found in D. nobile and has anticancer activity. It decreases viability of A549 cells when used at concentrations ranging from 2.5 to 15 µg/ml. It induces apoptosis in A549 cells when used at concentrations ranging from 1 to 10 µg/ml, as well as increases JNK phosphorylation and sensitizes A549 cells to cisplatin (Cay-13119) at 10 µg/ml. Dendrobine (50 mg/kg per day) reduces tumor growth in an A549 mouse xenograft model with an additive effect when used in combination with cisplatin.Formal Name: (2aS,4aS,5R,6S,7R,7aS,7bR)-decahydro-1,7b-dimethyl-6-(1-methylethyl)-7,5-(epoxymethano)-1H-cyclopent[cd]indol-9-one. CAS Number: 2115-91-5. Synonyms: (-)-Dendrobine. Molecular Formula: C16H25NO2. Formula Weight: 263.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: Methanol: Soluble. SMILES: CN1[C@]2([H])[C@]([H])(OC3=O)[C@@H](C(C)C)[C@@]3([H])[C@@]4([H])[C@]2(C)[C@@](CC4)([H])C1. InChi Code: InChI=1S/C16H25NO2/c1-8(2)11-12-10-6-5-9-7-17(4)14(16(9,10)3)13(11)19-15(12)18/h8-14H,5-7H2,1-4H3/t9-,10+,11+,12-,13-,14-,16+/m1/s1. InChi Key: RYAHJFGVOCZDEI-UFFNCVEVSA-N. Origin: Plant/Dendrobium stem.