Delpazolid

Description: Delpazolid (LCB01-0371), also known as LCB01-0371, is a new oxazolidinone with cyclic amidrazone. In vitro activity of LCB01-0371 against 624 clinical isolates was evaluated and compared with those of linezolid, vancomycin, and other antibiotics. LCB01-0371 showed good activity against Gram-positive pathogens. In vivo activity of LCB01-0371 against systemic infections in mice was also evaluated. LCB01-0371 was more active than linezolid against these systemic infections. LCB01-0371 showed bacteriostatic activity against Staphylococcus aureus. Target: Antibiotic, Antibacterial. Smiles: CN1CCN(C=N1)c1ccc(cc1F)N1C[C@H](CO)OC1=O. References: Jeong JW, et al.In vitro and in vivo activities of LCB01-0371, a new oxazolidinone.Antimicrob Agents Chemother. 2010 Dec,54(12):5359-62. Jeong JW1,