Dehydrocostus lactone

Dehydrocostus lactone is a natural sesquiterpene first isolated from costus root, which is used in traditional medicine. Dehydrocostus lactone has diverse anti-cancer properties in cells and animal models, causing cell cycle arrest, inducing apoptosis, diminishing multidrug resistance, and suppressing angiogenesis in cancer cells. It also has anti-inflammatory actions in cells, including the inhibition of signaling through STAT1 and STAT3.Formal Name: (3aS,6aR,9aR,9bS)-decahydro-3,6,9-tris(methylene)-azuleno[4,5-b]furan-2(3H)-one. CAS Number: 477-43-0. Synonyms: (-)-Dehydrocostus lactone. Molecular Formula: C15H18O2. Formula Weight: 230.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMSO: 2 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. SMILES: C=C([C@H](CC1)[C@H](O2)[C@]3([H])[C@](CCC3=C)([H])C1=C)C2=O. InChi Code: InChI=1S/C15H18O2/c1-8-4-7-12-10(3)15(16)17-14(12)13-9(2)5-6-11(8)13/h11-14H,1-7H2/t11-,12-,13-,14-/m0/s1. InChi Key: NETSQGRTUNRXEO-XUXIUFHCSA-N.