Dehydro Nifedipine

Dehydro nifedipine is an active metabolite of nifedipine (Cay-11106), a calcium channel blocker present in formulations used to treat hypertension and angina. Dehydro nifedipine is formed when nifedipine is metabolized by the cytochrome P450 (CYP) isomers CYP3A4 and CYP3A5. Dehydro nifedipine inhibits glucose uptake in PC-12 cells with an IC50 value of 130 µM.Formal Name: 2,6-dimethyl-4-(2-nitrophenyl)-3,5-dimethyl ester 3,5-pyridinedicarboxylic acid. CAS Number: 67035-22-7. Synonyms: BAY-b 4759. Molecular Formula: C17H16N2O6. Formula Weight: 344.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml, Ethanol: 3 mg/ml. lambdamax: 260 nm. SMILES: CC1=C(C(OC)=O)C(C2=CC=CC=C2[N+]([O-])=O)=C(C(OC)=O)C(C)=N1. InChi Code: InChI=1S/C17H16N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8H,1-4H3. InChi Key: UMQHJQGNGLQJPF-UHFFFAOYSA-N.