Decitabine

Description: Decitabine (Deoxycytidine) is a deoxycytidine analog, a DNA methyltransferase inhibitor with oral activity. Decitabine has antitumor activity and antimetabolic activity. Decitabine induces cell cycle arrest and apoptosis. Target: Nucleoside Antimetabolite/Analog, Apoptosis, DNA Methyltransferase. Smiles: Nc1ncn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)n1. References: Zhang G, et al. Decitabine inhibits the proliferation of human T-cell acute lymphoblastic leukemia molt4 cells and promotes apoptosis partly by regulating the PI3K/AKT/mTOR pathway. Oncol Lett. 2021 May,21(5):340.