DC-05

DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1, IC50 = 10.3 µM). It is selective for DNMT1 over DNMT3A and DNMT3B (IC50s = >200 µM), as well as the additional methyltransferases G9a, SUV39H1, MLL1, SET7/9, and PRMT1 (IC50s = >150, >150, >150, >150, and 37.1 µM, respectively). DC-05 (2.5-10 µM) reduces proliferation of HCT116 colon cancer cells.Formal Name: alpha-[[[2-(1H-indol-3-yl)ethyl]amino]methyl]-9H-carbazole-9-ethanol. CAS Number: 890643-16-0. Molecular Formula: C25H25N3O. Formula Weight: 383.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 12 mg/ml, DMSO: 11 mg/ml, Ethanol: Slightly soluble, PBS (pH 7.2): 0.3 mg/ml. lambdamax: 223, 235, 261, 292 nm. SMILES: OC(CN1C2=C(C3=C1C=CC=C3)C=CC=C2)CNCCC4=CNC5=C4C=CC=C5. InChi Code: InChI=1S/C25H25N3O/c29-19(16-26-14-13-18-15-27-23-10-4-1-7-20(18)23)17-28-24-11-5-2-8-21(24)22-9-3-6-12-25(22)28/h1-12,15,19,26-27,29H,13-14,16-17H2. InChi Key: LJWMTSMUQJNHOC-UHFFFAOYSA-N.