Dapoxetine Hydrochloride

Dapoxetine hydrochloride was initially designed as an antidepressant but was found more beneficial in the treatment of premature ejaculation due to its lack of significant effects on mood and quick adsorption and elimination kinetics. Dapoxetine is a centrally-acting SSRI that modulates serotonin levels in relevant areas such as the lateral paragigantocellular nucleus through inhibition of the serotonin transporter (SERT). This compound also decreases peak amplitude and accelerates the decay rate of current inactivation in a variety of voltage-gated K+ channels.