Dabcyl-YVADAPV-EDANS

Dabcyl-YVADAPV-EDANS is a fluorogenic substrate for caspase-1. Upon enzymatic cleavage by caspase-1, EDANS is separated from the Dabcyl quencher and can be used to quantify caspase-1 activity. EDANS displays excitation/emission maxima of 340/485 nm, respectively.Formal Name: N-[4-[[4-(dimethylamino)phenyl]azo]benzoyl]-L-tyrosyl-L-valyl-L-alanyl-L-alpha-aspartyl-L-alanyl-L-prolyl-N-[2-[(5-sulfo-1-naphthalenyl)amino]ethyl]-L-valinamide. CAS Number: 161877-70-9. Synonyms: Dabcyl-ICE-EDANS. Molecular Formula: C61H76N12O14S. Formula Weight: 1233.4. Purity: >95%. Formulation: (Request formulation change), A lyophilized powder. Solubility: 5% NH3 (Aqueous): 1 mg/ml. SMILES: CC(C)[C@@H](C(N[C@@H](C)C(N[C@@H](CC(O)=O)C(N[C@@H](C)C(N1CCC[C@H]1C(N[C@H](C(NCCNC2=C(C=CC=C3S(O)(=O)=O)C3=CC=C2)=O)C(C)C)=O)=O)=O)=O)=O)NC([C@H](CC4=CC=C(C=C4)O)NC(C5=CC=C(/N=N/C6=CC=C(N(C)C)C=C6)C=C5)=O)=O. InChi Code: InChI=1S/C61H76N12O14S/c1-34(2)52(59(82)63-30-29-62-46-14-9-13-45-44(46)12-10-16-50(45)88(85,86)87)69-58(81)49-15-11-31-73(49)61(84)37(6)65-56(79)48(33-51(75)76)66-54(77)36(5)64-60(83)53(35(3)4)68-57(80)47(32-38-17-27-43(74)28-18-38)67-55(78)39-19-21-40(22-20-39)70-71-41-23-25-42(26-24-41)72(7)8/h9-10,12-14,16-28,34-37,47-49,52-53,62,74H,11,15,29-33H2,1-8H3,(H,63,82)(H,64,83)(H,65,79)(H,66,77)(H,67,78)(H,68,80)(H,69,81)(H,75,76)(H,85,86,87)/b71-70+/t36-,37-,47-,48-,49-,52-,53-/m0/s1. InChi Key: VOOSFUAACNZZDI-NCIMJASNSA-N.