D-myo-Inositol-2,4,5-triphosphate (sodium salt)

The inositol phosphates (InsP) play a critical role as small, soluble second messengers in the transmission of cellular signals. The inositol phosphates (InsP) play a critical role as small, soluble second messengers in the transmission of cellular signals. The most studied InsP, D-myo-Inositol-2,4,5-triphosphate (sodium salt) (Ins(1,4,5)P3), more commonly referred to as IP3, is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate. Binding of Ins(1,4,5)P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium. Ins(2,4,5)P3 is a metabolically stable analog of Ins(1,4,5)P3 that is commonly used to study Ca2+ signaling pathways. Ins(2,4,5)P3 acts as a partial agonist at rat hepatic IP3 receptors, exhibiting 65% of the maximal Ca2+ response obtained with Ins(1,4,5)P3.Formal Name: D-myo-inositol-2,4,5-tris(hydrogen phosphate), trisodium salt. Synonyms: Ins(2,4,5)P3 (sodium salt), 2,4,5-IP3 (sodium salt). Molecular Formula: C6H12O15P3 . 3Na. Formula Weight: 486.0. Purity: >98%. Formulation: (Request formulation change), A lyophilized powder. SMILES: O[C@H]1[C@H](O)[C@@H](OP([O-])(O)=O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@H]1OP([O-])(O)=O.[Na+].[Na+].[Na+]. InChi Code: InChI=1S/C6H15O15P3.3Na/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12,,,/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18),,,/q,3*+1/p-3/t1-,2-,3-,4?,5?,6?,,,/m0.../s1. InChi Key: ZVCVTWVBDIPWPZ-UIEDNGEDSA-K.