D-myo-Inositol-1,2,6-triphosphate (sodium salt)

D-myo-Inositol-1,2,6-phosphate (Ins(1,2,6)-P3) is a member of the inositol phosphate (InsP) family of second messengers that play a critical role in the transmission of cellular signals. The most studied InsP, Ins(1,4,5)-P3 is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate. Binding of Ins(1,4,5)-P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium. Ins(1,2,6)-P3 (tested as the D/L racemic mixture) is ~1,000-fold less potent than Ins(1,4,5)-P3 at initiating Ca2+ release when injected into Xenopus oocytes.Formal Name: D-myo-inositol-1,2,6-tris(hydrogen phosphate), trisodium salt. Synonyms: Ins(1,2,6)-P3, 1,2,6-IP3. Molecular Formula: C6H12O15P3 . 3Na. Formula Weight: 486.0. Purity: >98%. Formulation: (Request formulation change), A lyophilized powder. SMILES: O[C@H]1[C@@H](OP([O-])(O)=O)[C@@H](OP([O-])(O)=O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@@H]1O.[Na+].[Na+].[Na+]. InChi Code: InChI=1S/C6H15O15P3.3Na/c7-1-2(8)4(19-22(10,11)12)6(21-24(16,17)18)5(3(1)9)20-23(13,14)15,,,/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18),,,/q,3*+1/p-3/t1-,2-,3+,4?,5?,6?,,,. InChi Key: JENABGGDGLKLTB-AJBPOAAQSA-K.