D-Kynurenine

D-Kynurenine is an antagonist of hydroxycarboxylic acid receptor 3 HCA3/GPR109B (EC50 = 2.61 µM in a luciferase reporter assay) and a metabolite of D-tryptophan. It increases levels of intracellular calcium and decreases forskolin-stimulated production of cAMP in CHO cells expressing human HCA3/GPR109B when used at concentrations of 10 and 100, or 1,000 µM, respectively. D-Kynurenine (10 µM) increases expression of vimentin and decreases expression of E-cadherin in 95D lung cancer cells. It has been used as a substrate in fluorometric assays for D-amino acid oxidase activity.Formal Name: alphaR,2-diamino-gamma-oxo-benzenebutanoic acid. CAS Number: 13441-51-5. Molecular Formula: C10H12N2O3. Formula Weight: 208.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: 0.5M HCl: 50 mg/ml. lambdamax: 228, 257, 370 nm. SMILES: NC1=C(C(C[C@@H](N)C(O)=O)=O)C=CC=C1. InChi Code: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m1/s1. InChi Key: YGPSJZOEDVAXAB-MRVPVSSYSA-N.