Cytochalasin D

The cytochalasins are cell-permeable fungal metabolites that inhibit actin polymerization. This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion. Cytochalasin D is a cell-permeable inhibitor that binds actin filaments, but not actin monomers, to inhibit polymerization at concentrations as low as 0.2 µM. In this way, it prevents the migration of tumor cells.Formal Name: (3S,3aR,4S,6S,6aR,7E,10S,12R,13E,15R,15aR)-15-(acetyloxy)-3,3a,4,5,6,6a,9,10,12,15-decahydro-6,12-dihydroxy-4,10,12-trimethyl-5-methylene-3-(phenylmethyl)-1H-cycloundec[d]isoindole-1,11(2H)-dione. CAS Number: 22144-77-0. Synonyms: NSC 209835. Molecular Formula: C30H37NO6. Formula Weight: 507.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: Dichloromethane: 10 mg/ml, DMSO: 100 mg/ml. SMILES: C=C1[C@@H](O)[C@@](/C=C/C[C@H](C)C(C(O)(C)/C=C/C2OC(C)=O)=O)([H])C23[C@@]([C@H](CC4=CC=CC=C4)NC3=O)([H])[C@@H]1C. InChi Code: InChI=1S/C30H37NO6/c1-17-10-9-13-22-26(33)19(3)18(2)25-23(16-21-11-7-6-8-12-21)31-28(35)30(22,25)24(37-20(4)32)14-15-29(5,36)27(17)34/h6-9,11-15,17-18,22-26,33,36H,3,10,16H2,1-2,4-5H3,(H,31,35)/b13-9+,15-14+/t17-,18+,22-,23-,24?,25-,26+,29?,30?/m0/s1. InChi Key: SDZRWUKZFQQKKV-PQNISXKDSA-N.