CyPPA

Description: CyPPA, a subtype-selective positive modulator of SK channels, decreased spontaneous firing rate, increased the duration of the apamin-sensitive afterhyperpolarization. Target: Dopamine Receptor, Potassium Channel. Smiles: Cc1cc(C)n(n1)-c1nc(C)cc(NC2CCCCC2)n1. References: Herrik KF, Redrobe JP, Holst D, Hougaard C, Sandager-Nielsen K, Nielsen AN, Ji H, Holst NM, Rasmussen HB, Nielsen EØ, Strøbæk D, Shepard PD, Christophersen P. CyPPA, a Positive SK3/SK2 Modulator, Reduces Activity of Dopaminergic Neurons, Inhibits Dopamine Release, and Counteracts Hyperdopaminergic Behaviors Induced by Methylphenidate. Front Pharmacol. 2012 Feb 13,3:11. doi: 10.3389/fphar.2012.00011. eCollection 2012. PubMed PMID: 22347859, PubMed Central PMCID: PMC3278045.