CYP1A1 inhibitor 8a

Description: CYP1A1 inhibitor 8a is a potent and selective CYP1A1 inhibitor. It antagonizes B[a]P mediated activation of aromatic hydrocarbon receptor (AhR) in yeast cells, thereby protects human cells from CYP1A1-mediated B[a]P toxicity. Target: Others. Smiles: O(C)C1=C(OC)C(OC)=CC(C=CC(=O)C=2C=CN=CC2)=C1. References: Horley NJ, Beresford KJM, Kaduskar S, Joshi P, McCann GJP, Ruparelia KC, Williams IS, Gatchie L, Sonawane VR, Bharate SB, Chaudhuri B. (E)-3-(3,4,5-Trimethoxyphenyl)-1-(pyridin-4-yl)prop-2-en-1-one, a heterocyclic chalcone is a potent and selective CYP1A1 inhibitor and cancer chemopreventive agent. Bioorg Med Chem Lett. 2017 Dec 15,27(24):5409-5414. doi: 10.1016/j.bmcl.2017.11.009. Epub 2017 Nov 6. PubMed PMID: 29138024.