Cyclosporin D

Cyclosporin D is a metabolite of cyclosporin A (Cay-12088), an immunosuppressant drug that binds cyclophilin D, inhibiting the phosphatase activity of calcineurin in T cells. Cyclosporin D displays about 10% lower immunosuppressant activity than cyclosporin A. Cyclosporin D has been used as an internal standard for the quantification of cyclosporin A.Formal Name: 7-L-valine-cyclosporin A. CAS Number: 63775-96-2. Molecular Formula: C63H113N11O12. Formula Weight: 1216.7. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Ethanol: Soluble. SMILES: O[C@@H]([C@](C(N[C@H](C(N(CC(N(C)[C@H](C(N[C@@H](C(C)C)C(N(C)[C@H]1CC(C)C)=O)=O)CC(C)C)=O)C)=O)C(C)C)=O)([H])N(C([C@H](C(C)C)N(C([C@@H](N(C([C@H](CC(C)C)N(C([C@H](NC([C@@H](NC1=O)C)=O)C)=O)C)=O)C)CC(C)C)=O)C)=O)C)[C@H](C)C/C=C/C. InChi Code: InChI=1S/C63H113N11O12/c1-26-27-28-41(16)53(76)52-57(80)67-49(38(10)11)61(84)68(19)33-48(75)69(20)44(29-34(2)3)56(79)66-50(39(12)13)62(85)70(21)45(30-35(4)5)55(78)64-42(17)54(77)65-43(18)58(81)71(22)46(31-36(6)7)59(82)72(23)47(32-37(8)9)60(83)73(24)5. InChi Key: ZNVBEWJRWHNZMK-SYOLRUPNSA-N.