Cyclophilin inhibitor 1

Description: Cyclophilin inhibitor 1 is an effective and orally bioavailable cyclophilin A inhibitor with a Kd of 5 nM, showing potent anti-HCV activity, and an EC50 for HCV 2a of 98 nM. Target: Others. Smiles: O=C1C2(/C=C/C=3C=C4C(=CC3)C=CC(=N4)[C@@H](C)NC(=O)[C@]5(NN(C(=O)[C@H](C)NC(=O)[C@H](C(C)C)O1)CCC5)[H])COCOC2. References: Mackman RL, et al. Discovery of a Potent and Orally Bioavailable Cyclophilin Inhibitor Derived from the Sanglifehrin Macrocycle. J Med Chem. 2018 Nov 8,61(21):9473-9499.