Cyclic ADP-Ribose (ammonium salt)

Cyclic ADP-ribose (cADP-ribose) is an endogenous metabolite of NAD+ that mobilizes the release of stored Ca2+ in the endoplasmic reticulum via ryanodine receptors in various cell types.{12737, 11940, 20368, 34320, 34319} This second messenger is generated via the cADP-ribose synthases CD38 and CD157.{20368, 34319, 34317} cADP-Ribose may also trigger the cell surface Ca2+ influx channel TRPM2 in a temperature-dependent manner. In vitro, cADP-ribose modulates Ca2+ signaling in rat and mouse cardiomyocytes treated with isoproterenol (Cay-15592), and treatment with this metabolite at 100 µM under heat stress conditions induces the release of oxytocin (Cay-11799) from the mouse hypothalamus.{34317, 34320}Formal Name: 1-beta-D-ribofuranosyl-adenosine 5'-(trihydrogen diphosphate), intramol. P',5''-ester, diammonium salt. Synonyms: cADP-Ribose, cADPR. Molecular Formula: C15H19N5O13P2 . 2NH4. Formula Weight: 575.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Water: Soluble. SMILES: N=C1C2=C(N3C=N2)N=CN1[C@@]4([H])[C@H](O)[C@H](O)[C@](COP(OP(OC[C@@]5([H])O[C@]3([H])[C@H](O)[C@@H]5O)([O-])=O)([O-])=O)([H])O4.[NH4+].[NH4+]. InChi Code: InChI=1S/C15H21N5O13P2.2H3N/c16-12-7-13-18-4-19(12)14-10(23)8(21)5(31-14)1-29-34(25,26)33-35(27,28)30-2-6-9(22)11(24)15(32-6)20(13)3-17-7,,/h3-6,8-11,14-16,21-24H,1-2H2,(H,25,26)(H,27,28),2*1H3/t5-,6-,8-,9-,10-,11-,14-,15-,,/m1../s1. InChi Key: IGYAJGYAGRVAJM-SPJXZGHLSA-N.