CWHM-12

Description: CWHM-12 is a potent inhibitor of alphaV integrins, with IC50 values of 0.2, 0.8, 1.5, and 1.8 nM for alphavbeta8, alphavbeta3, alphavbeta6, and alphavbeta1, respectively. Target: Integrin. Smiles: CC(C)(C)c1cc(Br)cc(c1)[C@H](CC(O)=O)NC(=O)CNC(=O)c1cc(O)cc(NC2=NCC(O)CN2)c1. References: Henderson NC, et al. Targeting of alphav integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nat Med. 2013 Dec,19(12):1617-24.