Curcumin analog C1

Curcumin analog C1 is a synthetic curcuminoid. It inhibits the proliferation of HCT116 colon cancer cells (GI50 = 4 µM). Curcumin analog C1 (1 µM) activates transcription factor EB (TFEB), inducing nuclear translocation in Neuro2a mouse neuroblastoma cells. It increases LC3-II levels and promotes autophagic flux in Neuro2a cells when used at a concentration of 1 µM. Curcumin analog C1 (10 and 25 mg/kg, p.o.) activates TFEB and increases autophagy and lysosome biogenesis in rat brain.Formal Name: (1E,4E)-1,5-bis(2-methoxyphenyl)-1,4-pentadien-3-one. CAS Number: 39777-61-2. Synonyms: GO-Y019, TFEB Activator 1. Molecular Formula: C19H18O3. Formula Weight: 294.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 1 mg/ml. lambdamax: 366 nm. SMILES: COC1=C(/C=C/C(/C=C/C2=C(OC)C=CC=C2)=O)C=CC=C1. InChi Code: InChI=1S/C19H18O3/c1-21-18-9-5-3-7-15(18)11-13-17(20)14-12-16-8-4-6-10-19(16)22-2/h3-14H,1-2H3/b13-11+,14-12+. InChi Key: RCZMPCUUTSDNAJ-PHEQNACWSA-N.