CUDC-907

CUDC-907 is a dual inhibitor of HDACs and phosphatidylinositol 3-kinases (PI3Ks). It inhibits HDAC activity in HeLa nuclear extracts (IC50 = 50s = 50s = 2/M phase and apoptosis and decreases cellular migration and invasion in FTC-133, THJ-29T, XTC-1, and 8505C thyroid cancer cell lines in a concentration-dependent manner. CUDC-907 (75 mg/kg) reduces tumor growth, the number of liver metastases, and HDAC2 expression in tumor tissue in the FTC-133 mouse xenograft model.Formal Name: N-hydroxy-2-[[[2-(6-methoxy-3-pyridinyl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]methylamino]-5-pyrimidinecarboxamide. CAS Number: 1339928-25-4. Molecular Formula: C23H24N8O4S. Formula Weight: 508.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. SMILES: CN(C1=NC=C(C(NO)=O)C=N1)CC2=CC3=NC(C4=CC=C(OC)N=C4)=NC(N5CCOCC5)=C3S2. InChi Code: InChI=1S/C23H24N8O4S/c1-30(23-25-11-15(12-26-23)22(32)29-33)13-16-9-17-19(36-16)21(31-5-7-35-8-6-31)28-20(27-17)14-3-4-18(34-2)24-10-14/h3-4,9-12,33H,5-8,13H2,1-2H3,(H,29,32). InChi Key: JOWXJLIFIIOYMS-UHFFFAOYSA-N.