CTS-1027

CTS-1027 is an inhibitor of matrix metalloproteinases (MMPs). It is selective for MMP-2, MMP-9, and MMP-13 (Kis= 0.22, 0.55, and 0.52 nM, respectively) over MMP-3 and MMP-1 (Kis= 9.3 and 590 nM, respectively). CTS-1027 (10 mg/kg) reduces hepatocyte apoptosis and bile infarcts and increases survival in a mouse model of bile duct ligation-induced cholestatic liver injury.Formal Name: 4-[[[4-(4-chlorophenoxy)phenyl]sulfonyl]methyl]tetrahydro-N-hydroxy-2H-pyran-4-carboxamide. CAS Number: 193022-04-7. Synonyms: Ro 113-0830, RS 130830. Molecular Formula: C19H20ClNO6S. Formula Weight: 425.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 10 mM. SMILES: O=C(C1(CS(=O)(C2=CC=C(C=C2)OC3=CC=C(C=C3)Cl)=O)CCOCC1)NO. InChi Code: InChI=1S/C19H20ClNO6S/c20-14-1-3-15(4-2-14)27-16-5-7-17(8-6-16)28(24,25)13-19(18(22)21-23)9-11-26-12-10-19/h1-8,23H,9-13H2,(H,21,22). InChi Key: ROSNVSQTEGHUKU-UHFFFAOYSA-N.