CS 2100

CS 2100 is a sphingosine-1-phosphate receptor 1 (S1P1) agonist. It selectively induces GTPgammaS binding in CHO-K1 cells expressing human or rat S1P1 (EC50s = 4 and 1.5 nM, respectively) over those expressing human or rat S1P3 (EC50s = >20 and 7.4 µM, respectively). CS 2100 (0.1 and 1 mg/kg) transiently reduces blood lymphocyte levels in rats with the levels returning to baseline within 24-48 hours. It reduces hind paw volume in a rat model of adjuvant-induced arthritis (ID50 = 0.44 mg/kg). CS 2100 (0.3 and 1 mg/kg) also decreases severity in a mouse model of experimental autoimmune encephalomyelitis (EAE).Formal Name: 1-[[4-ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]-3-azetidinecarboxylic acid. CAS Number: 913827-99-3. Molecular Formula: C25H23N3O4S. Formula Weight: 461.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Sparingly soluble: 1-10 mg/ml. SMILES: CCC1=C(SC(CN2CC(C(O)=O)C2)=C1)C3=NOC(C4=CC=C(OC5=CC=CC=C5)C=C4)=N3. InChi Code: InChI=1S/C25H23N3O4S/c1-2-16-12-21(15-28-13-18(14-28)25(29)30)33-22(16)23-26-24(32-27-23)17-8-10-20(11-9-17)31-19-6-4-3-5-7-19/h3-12,18H,2,13-15H2,1H3,(H,29,30). InChi Key: DWVJASHDNJMDNH-UHFFFAOYSA-N.