Cridanimod (sodium salt)

Cridanimod is an inducer of type I interferon (IFN) production. It induces IRF3 phosphorylation, IFN-beta production, and NF-kappaB activation in wild-type, but not in stimulator of interferon genes (STING) mutant, murine macrophages. In vivo, cridanimod (112-1,792 mg/kg) increases plasma levels of IFN in weanling and adult mice. Cridanimod inhibits viral infection in mouse models of Semliki forest, coxsackie B1, Columbia SK, herpes, and pseudorabies viruses with protective doses (PD50s) ranging from 17-320 mg/kg. It increases uterine expression of estrogen and progesterone receptors in ovariectomized rats. Cridanimod also reverses tamoxifen-induced decreases in progesterone receptor expression in young rats.Formal Name: 9-oxo-10(9H)-acridineacetic acid, monosodium salt. CAS Number: 58880-43-6. Synonyms: 10-Carboxymethyl-9-Acridanone. Molecular Formula: C15H10NO3 . Na. Formula Weight: 275.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 20 mg/ml. lambdamax: 216, 255, 400 nm. SMILES: O=C1C2=CC=CC=C2N(CC([O-])=O)C3=C1C=CC=C3.[Na+]. InChi Code: InChI=1S/C15H11NO3.Na/c17-14(18)9-16-12-7-3-1-5-10(12)15(19)11-6-2-4-8-13(11)16,/h1-8H,9H2,(H,17,18),/q,+1/p-1. InChi Key: FQMLTEAEJZVTAJ-UHFFFAOYSA-M.