CP 424174

Description: CP 424174 is an inhibitor of IL-1beta post-translational processing with IC50 of 210 nM. Inhibits the formation of mature IL-1beta. Indirectly inhibits NLRP3. Active in vivo and orally bioavailable. Target: IL Receptor. Smiles: CC(C)c1cc(Cl)cc(C(C)C)c1NC(=O)NS(=O)(=O)c1cccc(c1)C(C)(C)O. References: Perregaux D G , Mcniff P , Laliberte R , et al. Identification and characterization of a novel class of interleukin-1 post-translational processing inhibitors.[J]. Journal of Pharmacology & Experimental Therapeutics, 2001, 299(1):187.