CP 226,269

CP 226,269 is a dopamine D4 receptor agonist. It induces calcium flux in HEK293 cells co-expressing human dopamine D4, but not D2L or D3, receptors and Galphaqo5 (EC50s = 32, >10,000, and 985 nM, respectively). CP 226,269 induces phospholipid methylation in SK-N-MC neuroblastoma cells, which endogenously express dopamine D1 and D4 receptors (EC50 = 2.9 nM).Formal Name: 5-fluoro-2-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-1H-indole. CAS Number: 220941-93-5. Molecular Formula: C18H19FN4. Formula Weight: 310.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 31 mg/ml. SMILES: FC1=CC=C2NC(CN3CCN(CC3)C4=CC=CC=N4)=CC2=C1. InChi Code: InChI=1S/C18H19FN4/c19-15-4-5-17-14(11-15)12-16(21-17)13-22-7-9-23(10-8-22)18-3-1-2-6-20-18/h1-6,11-12,21H,7-10,13H2. InChi Key: PQOIDBZLMJMYCD-UHFFFAOYSA-N.