CP 154,526 (hydrochloride)

CP 154,526 is an antagonist of corticotropin-releasing factor receptor 1 (CRF1, Ki = 2.7 nM). It is selective for CRF1 over CRF2 (Ki = >10 µM). CP 154,526 inhibits CRF-induced increases in adrenocorticotropic hormone (ACTH) levels in rat plasma with an ID50 value of 10 mg/kg. It increases the time spent in the open arms of the elevated plus maze in rats when administered at a dose of 1 mg/kg. CP 154,526 (10 mg/kg, twice per day for 14 days) decreases immobility time in the forced swim test in a rat model of depressive-like behavior. It also decreases stress-induced reinstatement of cocaine or heroin self-administration in cocaine- and heroin-trained rats, respectively, when administered at doses of 15 and 30 mg/kg.Formal Name: N-butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, monohydrochloride. CAS Number: 257639-98-8. Molecular Formula: C23H32N4 . HCl. Formula Weight: 401.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 20 mg/ml, Ethanol: 20 mg/ml. lambdamax: 304 nm. SMILES: CC1=NC(N(CCCC)CC)=C2C(N(C3=C(C)C=C(C)C=C3C)C=C2C)=N1.Cl. InChi Code: InChI=1S/C23H32N4.ClH/c1-8-10-11-26(9-2)22-20-18(6)14-27(23(20)25-19(7)24-22)21-16(4)12-15(3)13-17(21)5,/h12-14H,8-11H2,1-7H3,1H. InChi Key: ZWDLBNCJWNENFF-UHFFFAOYSA-N.