Costunolide

Costunolide is a sesquiterpene lactone that is found naturally in certain plant extracts and in alternative medicine oils. It reduces growth (EC50 = 3-35 µM) and induces apoptosis in assorted cancer cell lines. Costunolide inhibits the activation of Akt (15 µM) in endometriotic epithelial cells and STAT3 activation in THP-1 cells (EC50 = 10 µM). It also inhibits telomerase activity in NALM-6 cells.Formal Name: 3aS,4,5,8,9,11aR-hexahydro-6E,10E-dimethyl-3-methylene-cyclodeca[b]furan-2(3H)-one. CAS Number: 553-21-9. Synonyms: Costus lactone, Melampolide, NSC 106404. Molecular Formula: C15H20O2. Formula Weight: 232.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1.6 mg/ml, DMF:PBS(pH7.2) (1:2): 0.3 mg/ml, DMSO: 0.1 mg/ml. SMILES: C/C1=C\[C@@H](OC(C2=C)=O)[C@H]2CC/C(C)=C\CC1. InChi Code: InChI=1S/C15H20O2/c1-10-5-4-6-11(2)9-14-13(8-7-10)12(3)15(16)17-14/h5,9,13-14H,3-4,6-8H2,1-2H3/b10-5-,11-9+/t13-,14+/m0/s1. InChi Key: HRYLQFBHBWLLLL-GRFSRWIASA-N.