CMP8

Description: CMP8 is a selective ligand for estrogen receptor. CMP8 binds to the mutant estrogen receptor ligand binding domain (ERLBD). CMP8 has IC50 values of 29 nM , 41 nM, 1100 nM and 2200 nM for MGERalpha, MGRERalpha, hERalpha and hERbeta, respectively. Target: Estrogen/progestogen Receptor, Estrogen Receptor/ERR. Smiles: C(C12C(C=3C(C1)=CC(O)=CC3)=C(C(=O)CC2)C4=CC=C(OCCN5CCCCC5)C=C4)C6=CC=C(Cl)C=C6. References: Miyazaki Y, et al. Destabilizing domains derived from the human estrogen receptor. J Am Chem Soc. 2012 Mar 7,134(9):3942-5.