CM10

CM10 is a pan-aldehyde dehydrogenase 1 (ALDH1A) inhibitor (IC50s = 1,700, 740, and 640 nM for human ALDH1A1, ALDH1A2, and ALDH1A3, respectively). It is selective for ALDH1A isoforms over ALDH2, -3A1, -4A1, -5A1, -1B1, and -1L1 at 20 µM. CM10 induces necroptosis in ovarian cancer stem cells.Formal Name: 2-(2-propen-1-yl)-6-[[(1-propyl-1H-benzimidazol-2-yl)amino]methyl]-phenol. CAS Number: 692269-09-3. Molecular Formula: C20H23N3O. Formula Weight: 321.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: OC1=C(CNC2=NC3=CC=CC=C3N2CCC)C=CC=C1CC=C. InChi Code: InChI=1S/C20H23N3O/c1-3-8-15-9-7-10-16(19(15)24)14-21-20-22-17-11-5-6-12-18(17)23(20)13-4-2/h3,5-7,9-12,24H,1,4,8,13-14H2,2H3,(H,21,22). InChi Key: ZFHWEWJDCFGRBO-UHFFFAOYSA-N.