Clidinium (bromide)

Clidinium is a gastrointestinal muscarinic receptor antagonist (Ki = 3 nM against [3H]quinuclidinyl benzilate binding in rat colonic enterocytes). Administration of clidinium, at a dose of 1 mg/kg, slows intestinal transit and induces constipation in mice. This clidinium-induced constipation induces serum hyperammonemia and decreases clonic, myoclonic, and tonic seizure thresholds in a murine pentylenetetrazole-induced epilepsy model.Formal Name: 3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-1-methyl-1-azoniabicyclo[2.2.2]octane, monobromide. CAS Number: 3485-62-9. Synonyms: Ro 2-3773. Molecular Formula: C22H26NO3 . Br. Formula Weight: 432.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: O=C(C(C1=CC=CC=C1)(O)C2=CC=CC=C2)OC3C[N+]4(C)CCC3CC4.[Br-]. InChi Code: InChI=1S/C22H26NO3.BrH/c1-23-14-12-17(13-15-23)20(16-23)26-21(24)22(25,18-8-4-2-5-9-18)19-10-6-3-7-11-19,/h2-11,17,20,25H,12-16H2,1H3,1H/q+1,/p-1. InChi Key: GKEGFOKQMZHVOW-UHFFFAOYSA-M.