Clenbuterol (hydrochloride)

Clenbuterol is an agonist of beta2-adrenergic receptors (beta2-ARs). It induces relaxation of equine tracheal muscle strips (EC50 = 2.1 nM). Clenbuterol (300 nM) increases the number of autophagosomes and autophagic flux in HepG2 cells. It increases blood flow to adipose tissue and induces weight gain in rats when administered at a dose of 2 mg/kg, as well as induces relaxation of bovine uterus. Clenbuterol also inhibits infection of MDCK cells by an H1N1 influenza isolate in vitro (EC50 = 9.4 µM). Formulations containing clenbuterol have been used in the treatment of airway obstruction in horses.Formal Name: 4-amino-3,5-dichloro-alpha-[[(1,1-dimethylethyl)amino]methyl]-benzenemethanol, monohydrochloride. CAS Number: 21898-19-1. Synonyms: NAB 365. Molecular Formula: C12H18Cl2N2O . HCl. Formula Weight: 313.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 20 mg/ml, Ethanol: 12 mg/ml, PBS (pH 7.2): 3 mg/ml. lambdamax: 211, 248, 302 nm. SMILES: ClC1=CC(C(O)CNC(C)(C)C)=CC(Cl)=C1N.Cl. InChi Code: InChI=1S/C12H18Cl2N2O.ClH/c1-12(2,3)16-6-10(17)7-4-8(13)11(15)9(14)5-7,/h4-5,10,16-17H,6,15H2,1-3H3,1H. InChi Key: OPXKTCUYRHXSBK-UHFFFAOYSA-N.