Cl-amidine hydrochloride

Description: Cl-amidine hydrochloride is an orally active peptidylarginine deiminase (PAD) inhibitor (IC50: 5.9 µM for PAD4) that induces apoptosis in cancer cells, induces microRNA (miR)-16 in vitro causing cell cycle arrest, prevents histone 3 citrullination, and inhibits neutrophil extracellular trap formation, improving survival in a murine sepsis model. Target: PAD, Apoptosis. Smiles: Cl.NC(=O)[C@H](CCCNC(=N)CCl)NC(=O)c1ccccc1. References: Yuan Luo, et al. Inhibitors and Inactivators of Protein Arginine Deiminase 4: Functional and Structural Characterization. Biochemistry. 2006 Oct 3, 45(39): 11727-11736.