CL 82,198

CL 82,198 is a selective inhibitor of human collagenase-3, also known as matrix metalloproteinase-13 (MMP-13), producing 89% inhibition at 10 µg/ml. It is without effect against MMP-1, MMP-9 or TNF-alpha converting enzyme. CL 82,198 is used to evaluate the role of MMP-13 in diverse processes, including cancer cell migration, acute lung injury, and joint degeneration associated with osteoarthritis.Formal Name: N-[4-(4-morpholinyl)butyl]-2-benzofurancarboxamide. CAS Number: 307002-71-7. Molecular Formula: C17H22N2O3. Formula Weight: 302.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 3 mg/ml, DMSO: 2.5 mg/ml, Ethanol: 25 mg/ml, PBS (pH 7.2): 0.25 mg/ml. lambdamax: 270 nm. SMILES: O=C(NCCCCN1CCOCC1)C2=CC3=CC=CC=C3O2. InChi Code: InChI=1S/C17H22N2O3/c20-17(16-13-14-5-1-2-6-15(14)22-16)18-7-3-4-8-19-9-11-21-12-10-19/h1-2,5-6,13H,3-4,7-12H2,(H,18,20). InChi Key: KUJQEQAVMNFFAO-UHFFFAOYSA-N.