CL 316,243

White to off-white powder. Soluble in water (5mg/ml). Slightly soluble in DMSO (0.5mg/ml). Chemical. CAS: 138908-40-4. Formula: C20H18ClNO7 . 2Na. MW: 419.8 . 46.0. Potent and selective beta3-adrenoceptor agonist (EC50=3nM) that is >10,000-fold selective over beta1 and beta2. Antidiabetic and antiobesity agent. Causes a rapid decrease in blood glucose level in mice. Increases brown adipose tissue thermogenesis. Induces functionally active mitochondrial uncoupling protein (UCP) in white fat. Restores the expression of down-regulated fatty acid oxidation genes in type 2 diabetic mice.