CIQ

CIQ is a substituted tetrahydroisoquinoline that acts as a subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors. It is without effect at subunits NR2A, NR2B, or glutamate receptors. CIQ enhances receptor responses two-fold (EC50 = 3 µM) by increasing channel opening frequency for glutamate or glycine. It is a positive allosteric modulator that does not alter agonist EC50 values.Formal Name: (3-chlorophenyl)[3,4-dihydro-6,7-dimethoxy-1-[(4-methoxyphenoxy)methyl]-2(1H)-isoquinolinyl]-methanone. CAS Number: 486427-17-2. Molecular Formula: C26H26ClNO5. Formula Weight: 467.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/mL, DMF:PBS (pH 7.2) (1:4): 0.2 mg/mL, DMSO: 25 mg/mL, Ethanol: 0.2 mg/mL. lambdamax: 284 nm. SMILES: COC1=CC=C(OCC2N(C(C3=CC(Cl)=CC=C3)=O)CCC4=C2C=C(OC)C(OC)=C4)C=C1. InChi Code: InChI=1S/C26H26ClNO5/c1-30-20-7-9-21(10-8-20)33-16-23-22-15-25(32-3)24(31-2)14-17(22)11-12-28(23)26(29)18-5-4-6-19(27)13-18/h4-10,13-15,23H,11-12,16H2,1-3H3. InChi Key: VYMILMYEENZHAR-UHFFFAOYSA-N.