Cimetidine-d3

Cimetidine-d3 is intended for use as an internal standard for the quantification of cimetidine (Cay-18743) by GC- or LC-MS. Cimetidine is a histamine H2 receptor antagonist (Ki = 0.6 µM). It also acts as an inverse agonist, inhibiting basal cAMP production in CHO cells expressing recombinant H2 receptors (IC50 = 1.2 µM). Cimetidine inhibits histamine-induced acid secretion from isolated bullfrog gastric mucosa (IC50 = 16 µM). In vivo, it inhibits histamine-induced gastric acid secretion in gastric fistulae and Heidenhain pouches in dogs (ED50 = 1.88 µmol/kg, p.o.). Cimetidine (20 mg/kg per day) also reduces tumor growth and neovascularization in a CMT93 colon cancer mouse syngeneic model.Formal Name: N-cyano-N''-methyl-d3-N'-[2-[[(4-methyl-1H-imidazol-5-yl)methyl]thio]ethyl]-guanidine. CAS Number: 1185237-29-9. Molecular Formula: C10H13D3N6S. Formula Weight: 255.4. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: Methanol: slightly soluble, Water: slightly soluble. SMILES: CC1=C(CSCC/N=C(NC([2H])([2H])[2H])/NC#N)N=CN1. InChi Code: InChI=1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14)/i2D3. InChi Key: AQIXAKUUQRKLND-BMSJAHLVSA-N.