Cilostamide

Cilostamide is a selective inhibitor of phosphodiesterase (PDE)3A and PDE3B with IC50 values of 27 and 50 nM, respectively. It is less selective for inhibition of PDE1, PDE2, PDE4, PDE5, and PDE7 (IC50s = 12 to > 300 µM). Cilostamide has been shown to inhibit thrombin-induced platelet aggregation with an IC50 value of 1.1 µM.Formal Name: N-cyclohexyl-4-[(1,2-dihydro-2-oxo-6-quinolinyl)oxy]-N-methyl-butanamide. CAS Number: 68550-75-4. Synonyms: OPC 3689. Molecular Formula: C20H26N2O3. Formula Weight: 342.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.25 mg/ml. lambdamax: 234, 270, 350 nm. SMILES: CN(C(CCCOC1=CC=C(NC(C=C2)=O)C2=C1)=O)C3CCCCC3. InChi Code: InChI=1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23). InChi Key: UIAYVIIHMORPSJ-UHFFFAOYSA-N.