Cilnidipine

Cilnidipine is a dihydropyridine calcium channel blocker that blocks L- and N-type high-voltage-activated calcium currents in rat hippocampal CA1 pyramidal neurons when used at a concentration of 10 µM. Cilnidipine (3 mg/kg) reduces the pressor response to acute cold stress, as well as mean blood pressure, in spontaneously hypertensive rats. It dose-dependently reduces mean blood pressure and cerebral vascular resistance without affecting cerebral blood flow in anesthetized rats at doses ranging from 3-100 µg/kg. Cilnidipine (100 µg/kg, i.p.) reduces cerebral infarction area in a rat model of focal brain ischemia.Formal Name: 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-(2-methoxyethyl) 5-[(2E)-3-phenyl-2-propen-1-yl] ester. CAS Number: 132203-70-4. Synonyms: FRC 8653. Molecular Formula: C27H28N2O7. Formula Weight: 492.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml, DMSO: 25 mg/ml, Ethanol: 2 mg/ml. lambdamax: 241, 358 nm. SMILES: CC1=C(C(OC/C=C/C2=CC=CC=C2)=O)C(C3=CC([N+]([O-])=O)=CC=C3)C(C(OCCOC)=O)=C(C)N1. InChi Code: InChI=1S/C27H28N2O7/c1-18-23(26(30)35-14-8-11-20-9-5-4-6-10-20)25(21-12-7-13-22(17-21)29(32)33)24(19(2)28-18)27(31)36-16-15-34-3/h4-13,17,25,28H,14-16H2,1-3H3/b11-8+. InChi Key: KJEBULYHNRNJTE-DHZHZOJOSA-N.