Cidofovir

Cidofovir is an acyclic nucleoside phosphonate antiviral agent and an active metabolite of brincidofovir (Cay-35062). It is formed from brincidofovir in MRC-5 human lung fibroblasts. Cidofovir inhibits CMV DNA synthesis in a cell-free assay, as well as replication of two CMV strains in plaque formation assays (IC50s = 0.1 and 0.07 µg/ml for Davis and AD-169 strains, respectively). It decreases mortality in mouse models of cowpox or vaccinia virus infections when administered at a dose of 15 mg/kg. Formulations containing cidofovir have been used in the treatment of CMV retinitis in patients with AIDS.Formal Name: P-[[(1S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]-phosphonic acid. CAS Number: 113852-37-2. Synonyms: GS-0504, (S)-HPMPC, (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine. Molecular Formula: C8H14N3O6P. Formula Weight: 279.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 2 mg/ml. SMILES: NC(C=CN1C[C@H](OCP(O)(O)=O)CO)=NC1=O. InChi Code: InChI=1S/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)/t6-/m0/s1. InChi Key: VWFCHDSQECPREK-LURJTMIESA-N.