Chrysin

Chrysin is a natural flavonoid with antioxidant, anti-inflammatory, and anticancer properties. It blocks COX-2 gene expression, PGE2 production, and hydroxyl radical formation in LPS-induced RAW 264.7 cells. Chrysin inhibits insulin-induced HIF-1alpha expression (~50% at 10 µM) in human prostate cancer DU145 cells and blocks DU145 xenograft-induced angiogenesis in vivo. In a mouse model of ischemia/reperfusion injury, chrysin decreased pro-inflammatory gene expression and oxidative stress, resulting in a reduction of infarct volume and neurological defects.Formal Name: 5,7-dihydroxy-2-phenyl-4H-1-benzopyran-4-one. CAS Number: 480-40-0. Synonyms: 5,7-DHF, 5,7-Dihydroxyflavone, NSC 407436. Molecular Formula: C15H10O4. Formula Weight: 254.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/m, DMSO: 30 mg/m. lambdamax: 212, 269, 315 nm. SMILES: O=C1C2=C(O)C=C(O)C=C2OC(C3=CC=CC=C3)=C1. InChi Code: InChI=1S/C15H10O4/c16-10-6-11(17)15-12(18)8-13(19-14(15)7-10)9-4-2-1-3-5-9/h1-8,16-17H. InChi Key: RTIXKCRFFJGDFG-UHFFFAOYSA-N. Origin: Synthetic.