Cholesteryl Hemisuccinate

Cholesteryl hemisuccinate is a cholesterol ester with anticancer activity. It inhibits the growth of murine C1498 myeloid and L1210 lymphocytic leukemia cells when used at concentrations of 50 and 150 µM, respectively. Cholesteryl hemisuccinate acts as an ionizable anionic detergent and is commonly used to stabilize unilamellar vesicles and liposomes. It has also been used as an emulsifying agent in various vesicular drug delivery systems for anticancer drugs, antibiotics, and oligonucleotides and to solubilize various proteins including chemokine receptor 1 as well as erythrocyte ghosts.Formal Name: (3beta)-cholest-5-en-3-ol 3-(hydrogen butanedioate). CAS Number: 1510-21-0. Synonyms: Cholesteryl hydrogen succinate. Molecular Formula: C31H50O4. Formula Weight: 486.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: Chloroform: 10 mg/ml. SMILES: C[C@]12C(C[C@@H](OC(CCC(O)=O)=O)CC2)=CC[C@]3([H])[C@]1([H])CC[C@@]4(C)[C@@]3([H])CC[C@@]4([C@@H](CCCC(C)C)C)[H]. InChi Code: InChI=1S/C31H50O4/c1-20(2)7-6-8-21(3)25-11-12-26-24-10-9-22-19-23(35-29(34)14-13-28(32)33)15-17-30(22,4)27(24)16-18-31(25,26)5/h9,20-21,23-27H,6-8,10-19H2,1-5H3,(H,32,33)/t21-,23+,24+,25-,26+,27+,30+,31-/m1/s1. InChi Key: WLNARFZDISHUGS-MIXBDBMTSA-N.