Chlorzoxazone

Chlorzoxazone is a centrally acting muscle relaxant and activator of small and intermediate conductance calcium-activated potassium channels (EC50s = 87 and 98 µM for KCa2.2 and KCa3.1, respectively). In vivo, chlorzoxazone (10 mg/kg) decreases alcohol but not water intake in a dose-dependent manner and reduces the propensity for rapid initial alcohol intake in rats with intermittent, but not continuous, access to alcohol. Formulations containing chlorzoxazone have been used in the treatment of pain and stiffness caused by muscle spasm. This product is also available as an analytical reference standard (Cay-25826).Formal Name: 5-chloro-2(3H)-benzoxazolone. CAS Number: 95-25-0. Synonyms: NSC 26189. Molecular Formula: C7H4ClNO2. Formula Weight: 169.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 16 mg/ml, DMSO: 10 mg/ml, Ethanol: 20 mg/ml, Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml. SMILES: ClC1=CC=C(OC(N2)=O)C2=C1. InChi Code: InChI=1S/C7H4ClNO2/c8-4-1-2-6-5(3-4)9-7(10)11-6/h1-3H,(H,9,10). InChi Key: TZFWDZFKRBELIQ-UHFFFAOYSA-N.