Chlorpromazine-d6 (hydrochloride)

Chlorpromazine-d6 (CPZ-d6) is intended for use as an internal standard for the quantification of CPZ (Cay-16129) by GC- or LC-MS. CPZ is a typical antipsychotic and an antagonist of dopamine D2, D3, and D4 receptors (Kis = 0.66, 0.84, and 1.2 nM, respectively) as well as the serotonin (5-HT) receptor subtype 5-HT2A (Ki = 1.8 nM). It is also an antagonist of histamine H1, alpha1A-, alpha2B-, and alpha2C-adrenergic, and M3 muscarinic acetylcholine receptors (Kis = 6, 0.28, 27, 46, and 47 nM, respectively). CPZ (10 mg/kg per day) increases latency to find the platform in a repealed acquisition water maze task and decreases vertical activity and stereotypic movements in the open field test in rats. CPZ (0.3, 1, and 3 mg/kg, s.c.) also reduces emesis induced by cisplatin (Cay-13119) in dogs.Formal Name: 2-chloro-N,N-di(methyl-d3)-10H-phenothiazine-10-propanamine, monohydrochloride. CAS Number: 1228182-46-4. Synonyms: CPZ-d6. Molecular Formula: C17H13ClD6N2S . HCl. Formula Weight: 361.4. Purity: >99% deuterated forms (d1-d6). Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: ClC1=CC=C(SC(C=CC=C2)=C2N3CCCN(C([2H])([2H])[2H])C([2H])([2H])[2H])C3=C1.Cl. InChi Code: InChI=1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20,/h3-4,6-9,12H,5,10-11H2,1-2H3,1H/i1D3,2D3,. InChi Key: FBSMERQALIEGJT-TXHXQZCNSA-N.