Chlorothalonil

Chlorothalonil is a broad-spectrum organochlorine fungicide that forms adducts with glutathione (GST, Cay-10007461) and cysteine residues on enzymes leading to GST depletion and enzyme deactivation, respectively. In vitro, it inhibits the growth of C. albicans and C. orbiculare fungi, S. aureus and B. cereus Gram-positive bacteria, and E. coli and P. aeruginosa Gram-negative bacteria (MICs = 0.7, 5, 1.3, 0.7, 0.5, and 1.7 µg/ml, respectively). In vivo, chlorothalonil (100 µg/ml) completely inhibits the growth of P. infestans, the tomato late blight pathogen, on tomato plants. It is toxic to aquatic organisms, including species of fish, crustaceans, molluscs, and algae with tenth percentile of toxicity values of 25.23, 40.59, 0.69, and 3.94 µg/L, respectively, as well as to other aquatic invertebrates. Chlorothalonil is carcinogenic in animal models and induces neoplasms in the forestomach and kidneys of rats when administered at a dose of 3.8 mg/kg per day, but it is not genotoxic. Formulations containing chlorothalonil have been used as fungicides in agriculture.Formal Name: 2,4,5,6-tetrachloro-1,3-benzenedicarbonitrile. CAS Number: 1897-45-6. Synonyms: 2,4,5,6-Tetrachloroisophthalonitrile. Molecular Formula: C8Cl4N2. Formula Weight: 265.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly Soluble, Methanol: Slightly Soluble. SMILES: ClC1=C(C#N)C(Cl)=C(Cl)C(Cl)=C1C#N. InChi Code: InChI=1S/C8Cl4N2/c9-5-3(1-13)6(10)8(12)7(11)4(5)2-14. InChi Key: CRQQGFGUEAVUIL-UHFFFAOYSA-N.