Chlormethiazole (hydrochloride)

Chlormethiazole is a potentiator of GABAA receptors. It potentiates GABA-induced currents in L-M(TK-) cells expressing alpha1beta1gamma2 or alpha1beta2gamma2 subunit-containing GABAA receptors with EC50 values of 0.8 and 3.4 µM, respectively. Chlormethiazole protects against seizures induced by maximal electroshock (MES) in mice (ED50 = 130.8 mg/kg). It reduces infarct volume in a rat model of focal ischemia induced by permanent middle cerebral artery occlusion (MCAO). Formulations containing chlormethiazole have been used in the treatment of acute alcohol withdrawal.Formal Name: 5-(2-chloroethyl)-4-methyl-thiazole, monohydrochloride. CAS Number: 6001-74-7. Synonyms: Clomethiazole. Molecular Formula: C6H8ClNS . HCl. Formula Weight: 198.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 213, 250 nm. SMILES: CC1=C(CCCl)SC=N1.Cl. InChi Code: InChI=1S/C6H8ClNS.ClH/c1-5-6(2-3-7)9-4-8-5,/h4H,2-3H2,1H3,1H. InChi Key: OFXYKSLKNMTBHK-UHFFFAOYSA-N.