Chenodeoxycholic acid

White to off-white crystalline powder. Soluble in DMSO, ethanol or dimethylformamide. Sparingly soluble in water. Cytotoxic hydrophobic primary bile acid, Activator of farnesoid X receptor (FXR), a nuclear receptor that is hepatoprotective and regulates bile acid synthesis (cholesterol 7alpha-hydroxylase (CYP7A1) suppression), conjugation and transport, as well as genes involved in lipid and glucose metabolism and, Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, insulin resistance, hyperlipidemia and atherosclerosis, Inhibitor of 5beta-reductase (AKR1D1), Potent selective inhibitor of DD2 (AKR1C2), Potent inhibitor of 11beta-HSD1 dehydrogenase, Changes tumor cell viability via IL-6 pathway, Anticancer compound. Apoptosis inducer, Immunosuppressive and anti-inflammatory compound. Modulates oxidative stress, Differentiation regulator of mouse embryonic stem cells, Used for dissolution of cholesterol gallstones.